What prognostic factors are important for resected intrahepatic cholangiocarcinoma?

Paik KY, Jung JC, Heo JS, Choi SH, Choi DW, Kim YI (2008) What prognostic factors are important for resected intrahepatic cholangiocarcinoma? J Gastroenterol Hepatol, 23(5):766-770

Introduction

Intrahepatic cholangiocarcinoma (ICC) are tumors that arise from either the second order branches of the intrahepatic bile duct or the more peripheral bile duct branches.

Methods

The cumulative and disease-free survival rates were calculated using the Kaplan–Meier method. The univariate correlation between the clinicopathological factors and survival were examined by the log-rank test. Factors independently associated with the survival were identified by the proportional hazard regression analysis. A P-value of less than 0.05 was considered to be statistically significant.

Intrahepatic cholangiocarcinoma: rising frequency, improved survival, and determinants of outcome after resection

Endo I, Gonen M, Yopp AC, et al. (2008) Intrahepatic cholangiocarcinoma: rising frequency, improved survival, and determinants of outcome after resection. Ann Surg, 248(1):84-96


Abstract
BACKGROUND: Despite data suggesting a rising worldwide incidence, intrahepatic cholangiocarcinoma (IHC) remains an uncommon disease. This study analyzes changes in IHC frequency, demographics, and treatment outcome in a consecutive and single institutional cohort. METHODS: Consecutive patients with confirmed IHC seen and treated over a 16-year period were included. The trend in IHC frequency over the study period was compared with that of hilar cholangiocarcinoma patients (HCCA) seen during the same time. Demographics and patient disposition, histopathologic, treatment, recurrence, and survival data were analyzed; changes in these variables over time were assessed.

Trends in Survival after Surgery for Cholangiocarcinoma: A 30-Year Population-Based SEER Database Analysis

Nathan H, Pawlik TM, Wolfgang CL, Choti MA, Cameron JL, Schulick RD (2007) Trends in survival after surgery for cholangiocarcinoma: a 30-year population-based SEER database analysis. J Gastrointest Surg, 11(11):1488-1496; discussion 1496-1487

Introduction
Data on long-term survival of patients after surgical resection are limited to single-institution case series. Reported 5-year survival rates in recent surgical series (irrespective of margin status) vary widely, from 17 to 40% for ICC6–14 and from 9 to 41% for ECC.

Aggressive surgical treatment of intrahepatic cholangiocarcinoma: predictors of outcomes

Roayaie S, Guarrera JV, Ye MQ, et al. (1998) Aggressive surgical treatment of intrahepatic cholangiocarcinoma: predictors of outcomes. J Am Coll Surg, 187(4):365-372
CODE: ICCSR98

Abstract: Median actuarial survivals were 42.9 6 8.9 months for resectable and 6.7 6 3.6 months for unresectable patients (p 5 0.005). Noncurative resection offers a survival advantage over no resection.

Introduction: Lack of etiologic factors such as intrahepatic lithiasis and liver flukes make this tumor 10 times less prevalent in Western countries.3,4

Liver Resection for Hilar and Peripheral Cholangiocarcinomas: A Study of 62 Cases

Madariaga JR, Iwatsuki S, Todo S, Lee RG, Irish W, Starzl TE (1998) Liver resection for hilar and peripheral cholangiocarcinomas: a study of 62 cases. Ann Surg, 227(1):70-79
CODE: ICCJRM98

Abstract: The survival rates for HCCA and PCCA were 79% (+8%) and 67% (+8%) at 1 year; 39% (+10%) and 40% (+9%) at 3 years; and 8% (+7%) and 35% (+10%) at 5 years, respectively.The median survival was 24 (±4) months for HCCA and 19 (+8) months for PCCA.

Surgical management of intrahepatic cholangiocarcinoma: a 31-year experience

Lieser MJ, Barry MK, Rowland C, Ilstrup DM, Nagorney DM (1998) Surgical management of intrahepatic cholangiocarcinoma: a 31-year experience. J Hepatobiliary Pancreat Surg, 5(1):41-47

Abstract: Intrahepatic cholangiocarcinoma (ICC) is the second most common malignant primary tumor of the liver. It is, though, a rare tumor and little is known regarding its natural history, clinicopathologic characteristics, or the outcomes of surgical therapy.

Hepatic Resection and Transplantation for Peripheral Cholangiocarcinoma

Casavilla FA, Marsh JW, Iwatsuki S, et al. (1997) Hepatic resection and transplantation for peripheral cholangiocarcinoma. J Am Coll Surg, 185(5):429-436

Abstract: Recent publications have questioned the role of orthotopic liver transplantation (OLT) in treating advanced or unresectable peripheral cholangiocarcinoma (Ch-Ca). We reviewed our experience with Ch-Ca to determine survival rates, recurrence patterns, and risk factors. Table 3