What prognostic factors are important for resected intrahepatic cholangiocarcinoma?

Paik KY, Jung JC, Heo JS, Choi SH, Choi DW, Kim YI (2008) What prognostic factors are important for resected intrahepatic cholangiocarcinoma? J Gastroenterol Hepatol, 23(5):766-770

Introduction

Intrahepatic cholangiocarcinoma (ICC) are tumors that arise from either the second order branches of the intrahepatic bile duct or the more peripheral bile duct branches.

Methods

The cumulative and disease-free survival rates were calculated using the Kaplan–Meier method. The univariate correlation between the clinicopathological factors and survival were examined by the log-rank test. Factors independently associated with the survival were identified by the proportional hazard regression analysis. A P-value of less than 0.05 was considered to be statistically significant.

Results
Overall Survival: The cumulative 1-, 3-, and 5-year survival rates for the 97 patients who underwent hepatic resection were 74.9%, 51.8%, and 31.1%, respectively. The patient survival according to the macroscopic type of the tumor was as follows: the median survival time of the patients with the MF type was 26.4 months, that of the IG type was 54.9 months, and that of the PI type was 9.6 months. A significant difference was observed in the survival rates among these three macroscopic types (P = 0.038).Table 2


Discussion

Nakeeb et al.2 reported that resection of ICC with a negative microscopic resection margin resulted in a 5-year survival rate of 57% and none of the patients with unresectable tumors survived for more than 25 months. We showed a 5-year disease-free survival rate of 2.1%, but the overall 5-year survival rate was 31.1%.